In Profhilo, L-HA is released slowly from the HA hybrid complexes and therefore does not trigger the first inflammatory cytokines making it very biocompatible. It also increases patient comfort during and after treatment and provides hydration to the skin especially in the epidermis – the Hydro effect.
H-HA in Profhilo provides a stable HA architecture in the dermis. This gives a volumetric effect – the Lift effect.
Another advantage of the stable co-operative hybrid complex when compared to H-HA and L-HA is the increase in the ex¬pression levels of type I and type III collagen in fibroblast and type IV and VII collagen in keratinocytes.
This results in improved skin quality and skin hydration both in the dermis and epidermis. There is also increased production of endogenous HA and elastin giving the skin a more youthful look.
HIGHEST CONCENTRATION ON THE MARKET OF HA – HYLAURONIC ACID
Profhilo contains 32mg of low molecular weight HA (80-100Kda) and 32 mg of high molecular weight HA (1100-1400Kda). This gives one of the highest concentration of HA on the market totalling 64 mg of HA in a 2ml prefilled syringe.